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-synuclein, that is a primary element of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, which happens to be an E3 ubiquitin ligase and triggers endoplasmic reticulum (ER) tension, suggest that dysfunction of your intracellular proteinase techniques, including ubiquitin-proteasome process or lysosomal process, which removes pointless h
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